Hydrochloric Acid → HCID 67442415、化合物
反応式
[OH:1][C@@H:2]1[C@H:6]2[N:7](C(OCC3C4C=CC=CC=4C4C3=CC=CC=4)=O)[CH2:8][C@H:9]([S:10][CH3:11])[C@H:5]2[O:4][CH2:3]1.Cl.O[C@@H]1[C@H]2N(C(OC(C)(C)C)=O)C[C@H](SC)[C@H]2OC1>O1CCOCC1>[CH3:11][S:10][C@H:9]1[CH2:8][NH:7][C@@H:6]2[C@@H:2]([OH:1])[CH2:3][O:4][C@H:5]12参加物
5
実験手順
Preparation of (3R,3aR,6S,6aS)(9H-fluoren-9-yl)methyl 3-hydroxy-6-(methylthio)tetrahydro-2H-furo[3,2-b]pyrrole-4(5H)-carboxylate (55) A solution of HCl in 1,4-dioxane (4M, 5.5 mL) was added to thiomethylether (54) (152 mg, 0.55 mmol). The mixture stirred for 1 hour then the solvents removed in vacuo. The residue was azeotroped with CH3CN (5 mL) to obtain (3R,3aR,6S,6aS)-6-(methylthio)hexahydro-2H-furo[3,2-b]pyrrol-3-ol which was used without further purification.
後処理
- customthe solvents removed in vacuo
- customThe residue was azeotroped with CH3CN (5 mL)
出典と根拠
- ORDレコード
- ord-201d49eb562b43d99282e62473d7cb08
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08039641B2
反応ノート
読み込み中…