Methylamine → HCID 10157541、化合物

HRID 1666071ノート

反応式

HRID 1666071 の反応式
[C:1]([C:3]1[C:4]([NH:20][C:21]2[CH:22]=[C:23]([CH:28]=[CH:29][C:30]=2[CH3:31])[C:24]([NH:26][CH3:27])=[O:25])=[N:5][C:6](S(C)(=O)=O)=[N:7][C:8]=1[N:9]([CH2:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH3:10])#[N:2].[CH3:32][NH2:33]>O1CCOCC1>[C:1]([C:3]1[C:4]([NH:20][C:21]2[CH:22]=[C:23]([CH:28]=[CH:29][C:30]=2[CH3:31])[C:24]([NH:26][CH3:27])=[O:25])=[N:5][C:6]([NH:33][CH3:32])=[N:7][C:8]=1[N:9]([CH2:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH3:10])#[N:2]

参加物

4

反応物 2

HCID 6329MethylamineHCID 10182026HCID 10182026、化合物

生成物 1

HCID 10157541HCID 10157541、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
80 °C

実験手順

3-{5-Cyano-6-[(2,2-dimethyl-propyl)-methyl-amino]-2-methanesulfonyl-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide (44 mg, 0.1 mmol) and methylamine (1 mL, 1M in THF) were mixed in p-dioxane (1 mL) in a sealed tube. The mixture was heated to 80° C. for overnight. The solvent was removed in vacuo, and the product (23 mg) was purified by the silica gel column chromatography. MS (m/z): 396 (M+H).

後処理

  1. customThe solvent was removed in vacuo
  2. customthe product (23 mg) was purified by the silica gel column chromatography

出典と根拠

ORDレコード
ord-de363e032862464b99999ee95b5ff130
出典データセット
uspto-grants-2011_10
特許番号
US08044040B2

反応ノート

読み込み中…