[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4,5-dihydro-1H-pyrazole-3-yl]methyl amine → HCID 44224963、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[N:11]=[C:10]([CH2:21][NH2:22])[CH2:9]2)=[CH:4][CH:3]=1>C(OCC)C.Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[N:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=3[Cl:20])[N:11]=[C:10]([CH2:21][NH2:22])[CH2:9]2)=[CH:6][CH:7]=1参加物
4
実験手順
A solution of [5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4,5-dihydro-1H-pyrazole-3-yl]methyl amine (19.33 g, 0.0545 mol) in diethylether (100 mL) and hydrogen chloride [2.0 M in diethyl ether (100 mL)] was stirred for 24 hours at room temperature and the solid formed was filtered off, washed with diethylether and dried to yield the [5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4,5-dihydro-1H-pyrazole-3-yl]methyl amine hydrochloride (19.41 g, 91%) as a yellow solid.