Ammonia → 2-Butoxy-9-(3-bromopropyl)-7,8-dihydro-8-oxoadenine

HRID 1666199ノート

反応式

HRID 1666199 の反応式
[Br:1][CH2:2][CH2:3][CH2:4][N:5]1[C:13]([O:14]C)=[N:12][C:11]2[C:6]1=[N:7][C:8]([O:17][CH2:18][CH2:19][CH2:20][CH3:21])=[N:9][C:10]=2[NH2:16].Cl.N>CO.O1CCOCC1>[CH2:18]([O:17][C:8]1[N:7]=[C:6]2[C:11]([NH:12][C:13](=[O:14])[N:5]2[CH2:4][CH2:3][CH2:2][Br:1])=[C:10]([NH2:16])[N:9]=1)[CH2:19][CH2:20][CH3:21]

参加物

6

反応物 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 231584909-(3-Bromopropyl)-2-butoxy-8-methoxy-9H-purin-6-amine

生成物 1

HCID 592880312-Butoxy-9-(3-bromopropyl)-7,8-dihydro-8-oxoadenine収率 92%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of the compound (1 g, 2.79 mmol) obtained in Step (i) in methanol (2 ml) was added a 4N-hydrochloric acid in dioxane (2 ml), and the mixture was stirred at room temperature for 3.5 hours. The mixture was neutralized by addition of 28% aqueous ammonia at 0° C., and the mixture was stirred for one hour. The precipitated crystals were collected by filtration, washed twice with water (2 ml) and further washed twice with methanol (2 ml), and dried to give the subtitle compound (882 mg) as a white solid. Yield: 92%

後処理

  1. stirringthe mixture was stirred for one hour
  2. filtrationThe precipitated crystals were collected by filtration
  3. washwashed twice with water (2 ml)
  4. washfurther washed twice with methanol (2 ml)
  5. customdried

出典と根拠

ORDレコード
ord-7481010a905a461d9e1c2415770efa28
出典データセット
uspto-grants-2011_10
特許番号
US08044056B2

反応ノート

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