3-Chloro-4-(3-fluorobenzyloxy)aniline → 4-[3-Chloro-4-(3-fluoro-benzyloxy)-phenylamino]-6-nitro-quinazoline

HRID 1666236ノート

反応式

HRID 1666236 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[N:10]=[CH:9][N:8]=[C:7]2Cl)([O-:3])=[O:2].[F:15][C:16]1[CH:17]=[C:18]([CH:29]=[CH:30][CH:31]=1)[CH2:19][O:20][C:21]1[CH:27]=[CH:26][C:24]([NH2:25])=[CH:23][C:22]=1[Cl:28]>C(O)(C)C>[Cl:28][C:22]1[CH:23]=[C:24]([NH:25][C:7]2[C:6]3[C:11](=[CH:12][CH:13]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=3)[N:10]=[CH:9][N:8]=2)[CH:26]=[CH:27][C:21]=1[O:20][CH2:19][C:18]1[CH:29]=[CH:30][CH:31]=[C:16]([F:15])[CH:17]=1

参加物

4

反応物 2

HCID 70592633-Chloro-4-(3-fluorobenzyloxy)anilineHCID 113562574-Chloro-6-nitroquinazoline

生成物 1

HCID 536304764-[3-Chloro-4-(3-fluoro-benzyloxy)-phenylamino]-6-nitro-quinazoline収率 67%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

In a flask equipped with a reflux condenser, 6-nitro-4-chloro-quinazoline 1.20 g (5.7 mmol) and 4-(3-fluorobenzyloxy)-3-chloroaniline 1.37 g (5.6 mmol) were dissolved into 80 mL of isopropanol, and the solution was refluxed for 3 h. Then a lot of yellow solid was deposited, which was filtered, dried under vacuum, and identified as the title compound. Yield: 67%.

後処理

  1. customIn a flask equipped with a reflux condenser
  2. temperaturethe solution was refluxed for 3 h
  3. filtrationwhich was filtered
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-af804869af834865bac3a9b22bbeca1a
出典データセット
uspto-grants-2011_10
特許番号
US08044063B2

反応ノート

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