Acetyl chloride → alpha-Acetoxy-3,4,5-trimethoxyphenyl-acetic acid

HRID 1666297ノート

反応式

HRID 1666297 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[CH:6]([OH:10])[C:7]([OH:9])=[O:8].[C:18](Cl)(=[O:20])[CH3:19]>>[C:18]([O:10][CH:6]([C:5]1[CH:11]=[C:12]([O:16][CH3:17])[C:13]([O:14][CH3:15])=[C:3]([O:2][CH3:1])[CH:4]=1)[C:7]([OH:9])=[O:8])(=[O:20])[CH3:19]

参加物

3

反応物 2

HCID 6367Acetyl chlorideHCID 139030963,4,5-Trimethoxymandelic acid

生成物 1

HCID 67081678alpha-Acetoxy-3,4,5-trimethoxyphenyl-acetic acid

実験手順

3,4,5-Trimethoxymandelic acid (80.5 g) was treated with acetyl chloride (150 ml) at room temperature for three hours. The clear solution was concentrated to dryness under vacuum, and the oily residue was crystallized from toluene (280 ml) giving pure α-acetoxy-3,4,5-trimethoxyphenylacetic acid (80.9 g), m.p. 135-139° C.

後処理

  1. concentrationThe clear solution was concentrated to dryness under vacuum
  2. customthe oily residue was crystallized from toluene (280 ml)

出典と根拠

ORDレコード
ord-a59961e20d414f499f2b7ec6ebbb983a
出典データセット
uspto-grants-2011_10
特許番号
US08044067B2

反応ノート

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