Methanol → N-(3-methoxybenzyl)-N-methyl-2-(3,5-dimetoxyphenyl)-2-(phenylsulfinyl)acetamide

HRID 1666309

反応式

HRID 1666309 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]([CH3:28])[C:8](=[O:27])[CH:9]([C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[C:19]([O:25][CH3:26])[CH:18]=1)[S:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.I([O-])(=O)(=O)=[O:33].[Na+].CO>O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:29]=[CH:30][CH:31]=1)[CH2:6][N:7]([CH3:28])[C:8](=[O:27])[CH:9]([C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[C:19]([O:25][CH3:26])[CH:18]=1)[S:10]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:33]

参加物

5

反応物 3

HCID 887MethanolHCID 23667635Sodium periodateHCID 67081986N-(3-methoxy-benzyl)-N-methyl-2-(3,5-dimetoxyphenyl)-2-(phenylsulfanyl)-acetamide

生成物 1

HCID 67081824N-(3-methoxybenzyl)-N-methyl-2-(3,5-dimetoxyphenyl)-2-(phenylsulfinyl)acetamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of the acetamide derivative from step 3 above (4.1 g), sodium metaperiodate (3.3 g), methanol (50 ml) and water (30 ml) was heated under reflux for 1.5 hours. The reaction mixture was filtered and the filtrate concentrated to dryness. The residue was purified by chromatography on silica gel using ethyl acetate as eluent, giving N-(3-methoxybenzyl)-N-methyl-2-(3,5-dimetoxyphenyl)-2-(phenylsulfinyl)acetamide (2.7 g) as a viscous oil.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 1.5 hours
  3. filtrationThe reaction mixture was filtered
  4. concentrationthe filtrate concentrated to dryness
  5. customThe residue was purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-ddf91edd5dd64618ac40df3249b9348b
出典データセット
uspto-grants-2011_10
特許番号
US08044067B2

関連ノート

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