Phenyl pyridin-3-ylcarbamate → 4-[3-(benzyloxy)benzylidene]-N-pyridin-3-ylpiperidine-1-carboxamide

HRID 1666349

反応式

HRID 1666349 の反応式
FC(F)(F)C(O)=O.[CH2:8]([O:15][C:16]1[CH:17]=[C:18]([CH:26]=[CH:27][CH:28]=1)[CH:19]=[C:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[N:29]1[CH:34]=[CH:33][CH:32]=[C:31]([NH:35][C:36](=O)[O:37]C2C=CC=CC=2)[CH:30]=1>>[CH2:8]([O:15][C:16]1[CH:17]=[C:18]([CH:26]=[CH:27][CH:28]=1)[CH:19]=[C:20]1[CH2:25][CH2:24][N:23]([C:36]([NH:35][C:31]2[CH:30]=[N:29][CH:34]=[CH:33][CH:32]=2)=[O:37])[CH2:22][CH2:21]1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

参加物

3

反応物 2

HCID 6935890Phenyl pyridin-3-ylcarbamateHCID 668761894-(3-Benzyloxy-benzylidene)-piperidine trifluoroacetate

生成物 1

HCID 249686854-[3-(benzyloxy)benzylidene]-N-pyridin-3-ylpiperidine-1-carboxamide収率 94.8%

実験手順

Following the procedure in Example 1, Step 6, 4-(3-benzyloxy-benzylidene)-piperidine trifluoroacetate (550 mg, 1.4 mmol, from Step 3) and phenyl pyridin-3-ylcarbamate (331 mg, 1.55 mmol) were used to provide the title compound (530 mg). MS (APCI 10 V) AP+ 400.2; 1H NMR (400 MHz, CD3OD) δ ppm 2.40-2.46 (m, 2H) 2.46-2.52 (m, 2H) 3.48-3.54 (m, 2H) 3.60-3.66 (m, 2H) 5.08 (s, 2H) 6.40 (s, 1H) 6.76-6.89 (m, 3H) 7.22 (t, J=8.09 Hz, 1H) 7.26-7.46 (m, 5H) 7.86-7.95 (m, J=8.36, 2.48, 1.45, 0.89 Hz, 1H) 8.16 (dd, J=4.81, 1.40 Hz, 1H) 8.58 (d, J=2.53 Hz, 1H).

出典と根拠

ORDレコード
ord-e100412d3f624df5936a45b1e4766466
出典データセット
uspto-grants-2011_10
特許番号
US08044052B2

関連ノート

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