Water → Mupirocin Calcium

HRID 16665

反応式

HRID 16665 の反応式
[CH3:1][C@H:2]([C@H:6]1[C@H:8]([CH2:9][C@H:10]2[CH2:15][O:14][C@@H:13]([CH2:16]/[C:17](/[CH3:33])=[CH:18]/[C:19]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([O-:32])=[O:31])=[O:20])[C@H:12]([OH:34])[C@@H:11]2[OH:35])[O:7]1)[C@H:3]([CH3:5])[OH:4].[CH3:36][C@H:37]([C@H:41]1[C@H:43]([CH2:44][C@H:45]2[CH2:50][O:49][C@@H:48]([CH2:51]/[C:52](/[CH3:68])=[CH:53]/[C:54]([O:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][C:65]([O-:67])=[O:66])=[O:55])[C@H:47]([OH:69])[C@@H:46]2[OH:70])[O:42]1)[C@H:38]([CH3:40])[OH:39].[Ca+2:71].[OH2:72]>CO>[CH3:1][C@H:2]([C@H:6]1[C@H:8]([CH2:9][C@H:10]2[CH2:15][O:14][C@@H:13]([CH2:16]/[C:17](/[CH3:33])=[CH:18]/[C:19]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([O-:32])=[O:31])=[O:20])[C@H:12]([OH:34])[C@@H:11]2[OH:35])[O:7]1)[C@H:3]([CH3:5])[OH:4].[CH3:36][C@H:37]([C@H:41]1[C@H:43]([CH2:44][C@H:45]2[CH2:50][O:49][C@@H:48]([CH2:51]/[C:52](/[CH3:68])=[CH:53]/[C:54]([O:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][C:65]([O-:67])=[O:66])=[O:55])[C@H:47]([OH:69])[C@@H:46]2[OH:70])[O:42]1)[C@H:38]([CH3:40])[OH:39].[OH2:72].[OH2:4].[Ca+2:71]

参加物

4

反応物 2

HCID 962WaterHCID 6435927Bactroban2 回

生成物 1

HCID 5282317Mupirocin Calcium

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Amorphous mupirocin calcium (5.00 g, 4.80 mmole) was dissolved in methanol (15 ml) and stirred to give a clear solution. Water (10 ml) was added to the solution. Methanol from the solution was evaporated at reduced pressure to give a final volume of 7 ml. The mupirocin calcium solution was allowed to crystallize for 60 h at 5° C. The crystalline product was filtered and washed with water (5 ml). The product was dried at 30° C. for 12 h.

後処理

  1. customto give a clear solution
  2. customMethanol from the solution was evaporated at reduced pressure
  3. customto give a final volume of 7 ml
  4. customto crystallize for 60 h at 5° C
  5. filtrationThe crystalline product was filtered
  6. washwashed with water (5 ml)
  7. customThe product was dried at 30° C. for 12 h.

出典と根拠

ORDレコード
ord-ec4f4bb3bf064bed92ba29c1ae4fe37f
出典データセット
uspto-grants-2010_06
特許番号
US07737177B2

関連ノート

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