Water → N-(2,6-diisopropylphenyl)-2-(2,4-dioxo-1-phenyl-1,3-diazaspiro[4.4]non-3-yl)acetamide

HRID 1666723

反応式

HRID 1666723 の反応式
C(=O)([O-])[O-].[K+].[K+].[C:7]1([N:13]2[C:17]3([CH2:21][CH2:20][CH2:19][CH2:18]3)[C:16](=[O:22])[NH:15][C:14]2=[O:23])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.Cl[CH2:25][C:26]([NH:28][C:29]1[C:34]([CH:35]([CH3:37])[CH3:36])=[CH:33][CH:32]=[CH:31][C:30]=1[CH:38]([CH3:40])[CH3:39])=[O:27].O>CN(C)C=O>[CH:38]([C:30]1[CH:31]=[CH:32][CH:33]=[C:34]([CH:35]([CH3:36])[CH3:37])[C:29]=1[NH:28][C:26](=[O:27])[CH2:25][N:15]1[C:16](=[O:22])[C:17]2([CH2:21][CH2:20][CH2:19][CH2:18]2)[N:13]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:14]1=[O:23])([CH3:39])[CH3:40]

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 23637742-Chloro-N-(2,6-diisopropylphenyl)acetamideHCID 674464041-Phenyl-1,3-diazaspiro[4.4]nonane-2,4-dione

生成物 1

HCID 25226594N-(2,6-diisopropylphenyl)-2-(2,4-dioxo-1-phenyl-1,3-diazaspiro[4.4]non-3-yl)acetamide収率 51.6%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

80 mg (0.57 mmol) of potassium carbonate are added to a solution of 120 mg (0.52 mmol) of 1-phenyl-1,3-diazaspiro[4.4]nonane-2,4-dione and 145 mg (0.57 mmol) of 2-chloro-N-(2,6-diisopropylphenyl)acetamide in 20 ml of dimethylformamide. The reaction medium is stirred at room temperature for 24 hours. It is then poured into water and extracted with ethyl acetate. The organic phases are collected, washed with water and dried over sodium sulfate. The solvents are evaporated. The residue is chromatographed on silica gel (heptane and then heptane/ethyl acetate 80/20, v/v). 120 mg of N-(2,6-diisopropylphenyl)-2-(2,4-dioxo-1-phenyl-1,3-diazaspiro[4.4]non-3-yl)acetamide are obtained in the form of a white solid. Yield=51%, m.p.=275-7° C.

後処理

  1. extractionextracted with ethyl acetate
  2. customThe organic phases are collected
  3. washwashed with water
  4. dry with materialdried over sodium sulfate
  5. customThe solvents are evaporated
  6. customThe residue is chromatographed on silica gel (heptane

出典と根拠

ORDレコード
ord-669f38638c9d4929801802c3f4a7f395
出典データセット
uspto-grants-2011_10
特許番号
US08044082B2

関連ノート

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