Bactroban → Mupirocin Calcium
反応式
[CH3:1][C@H:2]([C@H:6]1[C@H:8]([CH2:9][C@H:10]2[CH2:15][O:14][C@@H:13]([CH2:16]/[C:17](/[CH3:33])=[CH:18]/[C:19]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([O-:32])=[O:31])=[O:20])[C@H:12]([OH:34])[C@@H:11]2[OH:35])[O:7]1)[C@H:3]([CH3:5])[OH:4].[CH3:36][C@H:37]([C@H:41]1[C@H:43]([CH2:44][C@H:45]2[CH2:50][O:49][C@@H:48]([CH2:51]/[C:52](/[CH3:68])=[CH:53]/[C:54]([O:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][C:65]([O-:67])=[O:66])=[O:55])[C@H:47]([OH:69])[C@@H:46]2[OH:70])[O:42]1)[C@H:38]([CH3:40])[OH:39].[Ca+2:71]>O>[CH3:1][C@H:2]([C@H:6]1[C@H:8]([CH2:9][C@H:10]2[CH2:15][O:14][C@@H:13]([CH2:16]/[C:17](/[CH3:33])=[CH:18]/[C:19]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([O-:32])=[O:31])=[O:20])[C@H:12]([OH:34])[C@@H:11]2[OH:35])[O:7]1)[C@H:3]([CH3:5])[OH:4].[CH3:36][C@H:37]([C@H:41]1[C@H:43]([CH2:44][C@H:45]2[CH2:50][O:49][C@@H:48]([CH2:51]/[C:52](/[CH3:68])=[CH:53]/[C:54]([O:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][C:65]([O-:67])=[O:66])=[O:55])[C@H:47]([OH:69])[C@@H:46]2[OH:70])[O:42]1)[C@H:38]([CH3:40])[OH:39].[OH2:4].[OH2:4].[Ca+2:71]参加物
3
試薬・触媒・溶媒 1
反応条件
- 温度
- 5 °C
実験手順
Amorphous mupirocin calcium (20.00 g, 19.20 mmole) was added into water (20 ml) under stirring. The slurry was stirred for 0.5 hour, and then it was cooled to 5° C. The mupirocin calcium solution was allowed to crystallize for 16 h. The crystal slurry was diluted with 15 ml water, and the crystals were filtered and washed with water (5 ml). The product (17.1 g) was dried at 35° C. for 12 h.