2-methylthio-5-trifluoromethyl-1H-indole → 5-(trifluoromethyl)-1H-indole
反応式
CS[C:3]1[NH:4][C:5]2[C:10]([CH:11]=1)=[CH:9][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:7][CH:6]=2>[Ni].C(O)C>[F:15][C:12]([F:13])([F:14])[C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][CH:3]=[CH:11]2参加物
4
実験手順
Combine moist Raney nickel (330 g), 2-methylthio-5-trifluoromethyl-1H-indole (33.8 g, 146.2 mmol) and absolute ethanol (850 ml) and stir. After 1.5 hours, filter the mixture through celite and wash the celite with ethanol (500 ml). Evaporate the filtrate to dryness, add toluene (20 ml) and evaporate and dry to give 5-trifluoromethylindole: mp=55-60° C.
後処理
- filtrationfilter the mixture through celite
- washwash the celite with ethanol (500 ml)
- customEvaporate the filtrate to dryness
- additionadd toluene (20 ml)
- customevaporate
- customdry
出典と根拠
- ORDレコード
- ord-548fa6aad71648358d3f513c587c77db
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08044090B2
反応ノート
読み込み中…