化工社化工社 化学情報印刷レポート · 研究参考用
1-Methylpiperazine → Olanzapine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methylpiperazine | HCID 53167 | — |
| 反応物 | 2-(2-Aminoanilino)-5-methylthiophene-3-carbonitrile | HCID 67445262 | — |
| 生成物 | Olanzapine | HCID 135398745 | — |
反応手順
The process disclosed herein comprises reaction of 2-(2-aminoanilino)-5-methylthiophene-3-carbonitrile [10] with N-methylpiperazine in conjunction with N-methyl piperazine acid salt to give Olanzapine. The reaction is carried out at 90-138° C., preferably at 110-125° C. in 6-12 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08044196B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-5e13e6863e2544d6bf3dbc3514595fe8 |
| 出典メモ | uspto-grants-2011_10 |