3,3-Diphenylpyrrolidine → 1-{2-[3,3-Bis(4-fluorophenyl)pyrrolidin-1-yl]-2-oxoethyl}-3,3-diphenylpyrrolidin-2-one
反応式
[O:1]=[C:2]1[C:6]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:5][CH2:4][N:3]1[CH2:19][C:20](O)=[O:21].FC1C=CC(C2(C3C=CC(F)=CC=3)CCCN(CC(O)=O)C2=O)=CC=1.[F:48][C:49]1[CH:54]=[CH:53][C:52]([C:55]2([C:60]3[CH:65]=[CH:64][C:63]([F:66])=[CH:62][CH:61]=3)[CH2:59][CH2:58][NH:57][CH2:56]2)=[CH:51][CH:50]=1.C1(C2(C3C=CC=CC=3)CCNC2)C=CC=CC=1>>[F:48][C:49]1[CH:54]=[CH:53][C:52]([C:55]2([C:60]3[CH:65]=[CH:64][C:63]([F:66])=[CH:62][CH:61]=3)[CH2:59][CH2:58][N:57]([C:20](=[O:21])[CH2:19][N:3]3[CH2:4][CH2:5][C:6]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=4)([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[C:2]3=[O:1])[CH2:56]2)=[CH:51][CH:50]=1参加物
5
反応物 4
生成物 1
実験手順
The title compound was prepared using the procedure described in Example 172 substituting 2-(2-oxo-3,3-diphenylpyrrolidin-1-yl)acetic acid from Example 1C for 2-(3,3-bis(4-fluorophenyl)-2-oxopiperidin-1-yl)acetic acid and 3,3-bis(4-fluorophenyl)pyrrolidine from Example 203A for 3,3-diphenylpyrrolidine. 1H NMR (300 MHz, CDCl3) δ ppm 7.44-6.86 (m, 18H), 4.27-3.98 (m, 4H), 3.55 (dq, J=6.7, 9.6, 3H), 3.41 (t, J=6.7, 1H), 2.82 (q, J=6.5, 2H), 2.50 (dt, J=6.8, 21.3, 2H); MS (DCI) m/z 537.2 (M+H)+.
出典と根拠
- ORDレコード
- ord-94fdd312be52419e84de0d1b59700d2b
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08044069B2
反応ノート
読み込み中…