Sulfuric Acid → Methyl 2,5-dibromo-4-methylbenzoate

HRID 1667328ノート

反応式

HRID 1667328 の反応式
[Br:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:8]([Br:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].S(=O)(=O)(O)O.[C:18](OCC)(=O)C>CO>[Br:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:8]([Br:12])=[CH:7][C:3]=1[C:4]([O:6][CH3:18])=[O:5]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 8857Ethyl AcetateHCID 232948852,5-Dibromo-4-methylbenzoic acid

生成物 1

HCID 26338328Methyl 2,5-dibromo-4-methylbenzoate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2,5-dibromo-4-methylbenzoic acid 5.88 g, 20 mmol) in 50 mL of methanol was added 0.2 mL of concentrated sulfuric acid. The resulting solution was refluxed for 24 hours. Evaporation of the solvent gave a residue, which was redissolved into 100 mL of ethyl acetate. The organic layer was washed with saturated sodium biocarbonate solution, water and brine. The resulting organic layer was dried over sodium sulfate. Filtration off sodium sulfate and evaporation of the solvent gave methyl 2,5-dibromo-4-methylbenzoate as a white solid: 6.20 g (100%).

後処理

  1. temperatureThe resulting solution was refluxed for 24 hours
  2. customEvaporation of the solvent
  3. customgave a residue, which
  4. washThe organic layer was washed with saturated sodium biocarbonate solution, water and brine
  5. dry with materialThe resulting organic layer was dried over sodium sulfate
  6. filtrationFiltration
  7. customoff sodium sulfate and evaporation of the solvent

出典と根拠

ORDレコード
ord-83edb0e976ef4969932a94916f9cc6dc
出典データセット
uspto-grants-2011_10
特許番号
US08044212B2

反応ノート

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