Methanesulfonic acid 3-{4-[6-amino-5-(4-fluoro-3-methyl-benzoyl)-2-oxo-2H-pyridin-1-yl]-3,5-difluorophenoxy}propyl ester → Cyclopentyl(S)-2-(3-{4-[6-Amino-5-(4-fluoro-3-methylbenzoyl)-2-oxo-2H-pyridin-1-yl]-3,5-difluorophenoxy}propylamino)-3-phenylpropionate

HRID 1667368

反応式

HRID 1667368 の反応式
[NH2:1][C:2]1[N:7]([C:8]2[C:22]([F:23])=[CH:21][C:11]([O:12][CH2:13][CH2:14][CH2:15]OS(C)(=O)=O)=[CH:10][C:9]=2[F:24])[C:6](=[O:25])[CH:5]=[CH:4][C:3]=1[C:26](=[O:35])[C:27]1[CH:32]=[CH:31][C:30]([F:33])=[C:29]([CH3:34])[CH:28]=1.S(C1C=CC(C)=CC=1)(O)(=O)=O.[CH:47]1([O:52][C:53](=[O:63])[C@H:54]([CH2:56][C:57]2[CH:62]=[CH:61][CH:60]=[CH:59][CH:58]=2)[NH2:55])[CH2:51][CH2:50][CH2:49][CH2:48]1>>[NH2:1][C:2]1[N:7]([C:8]2[C:22]([F:23])=[CH:21][C:11]([O:12][CH2:13][CH2:14][CH2:15][NH:55][C@@H:54]([CH2:56][C:57]3[CH:58]=[CH:59][CH:60]=[CH:61][CH:62]=3)[C:53]([O:52][CH:47]3[CH2:51][CH2:50][CH2:49][CH2:48]3)=[O:63])=[CH:10][C:9]=2[F:24])[C:6](=[O:25])[CH:5]=[CH:4][C:3]=1[C:26](=[O:35])[C:27]1[CH:32]=[CH:31][C:30]([F:33])=[C:29]([CH3:34])[CH:28]=1

参加物

3

反応物 2

HCID 57658377Methanesulfonic acid 3-{4-[6-amino-5-(4-fluoro-3-methyl-benzoyl)-2-oxo-2H-pyridin-1-yl]-3,5-difluorophenoxy}propyl esterHCID 86629432L-phenylalanine cyclopentyl ester tosylate2 回

生成物 1

HCID 57658343Cyclopentyl(S)-2-(3-{4-[6-Amino-5-(4-fluoro-3-methylbenzoyl)-2-oxo-2H-pyridin-1-yl]-3,5-difluorophenoxy}propylamino)-3-phenylpropionate

実験手順

From Intermediate 4D and L-phenylalanine cyclopentyl ester tosylate salt (Intermediate 16), LCMS purity 97%, m/z 648 [M+H]+, 1H NMR (400 MHz, CD3OD), δ: 1.20-1.90 (9H, m), 2.25 (2H, m), 2.35 (3H, s), 3.15 (1H, m), 3.45 (1H, m), 4.25 (2H, m), 4.40 (1H, d), 5.20 (2H, m), 5.82 (1H, d), 6.95 (2H, m), 7.20 (1H, m), 7.30-7.50 (7H, m), 7.75 (1H, d).

出典と根拠

ORDレコード
ord-fceea83f9f3848489f389e566970bb58
出典データセット
uspto-grants-2011_10
特許番号
US08044211B2

関連ノート

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