Hydrochloric Acid → (3-Aminomethyl-phenyl)-(2-morpholin-4-yl-ethyl)-amine hydrochloride

HRID 1667497ノート

反応式

HRID 1667497 の反応式
C(OC(=O)[NH:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([NH:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH:9]=1)(C)C.[ClH:24]>CO>[ClH:24].[NH2:6][CH2:7][C:8]1[CH:9]=[C:10]([NH:14][CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH:11]=[CH:12][CH:13]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 67415913[3-(2-Morpholin-4-yl-ethylamino)-benzyl]-carbamic acid isopropyl ester

生成物 1

HCID 67416818(3-Aminomethyl-phenyl)-(2-morpholin-4-yl-ethyl)-amine hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of [3-(2-morpholin-4-yl-ethylamino)-benzyl]-carbamic acid isopropyl ester (200 mg, 0.596 mmol), methanol (4 mL) and 4.89N isopropanolic hydrochloric acid (2.4 mL) was stirred at room temperature overnight. The reaction was concentrated and dried to yield (3-aminomethyl-phenyl)-(2-morpholin-4-yl-ethyl)-amine hydrochloride (212 mg) as an orange solid. m/z (M+1) 236.04.

後処理

  1. concentrationThe reaction was concentrated
  2. customdried

出典と根拠

ORDレコード
ord-d0461efb317140da8943833de944b134
出典データセット
uspto-grants-2011_10
特許番号
US08044041B2

反応ノート

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