Methyl 2-(3,4-dimethoxyphenyl)-2-hydroxyacetate → Methyl 2-(2-fluoro-4,5-dimethoxyphenyl)-2-hydroxyacetate

反応式

[F:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:3]=1[CH:4]=[O:5].COC1C=C(C(O)[C:25]([O:27][CH3:28])=[O:26])C=CC=1OC>>[F:1][C:2]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:3]=1[CH:4]([OH:5])[C:25]([O:27][CH3:28])=[O:26]

参加物

反応物 2

HCID 597469Methyl 2-(3,4-dimethoxyphenyl)-2-hydroxyacetate

HCID 6035952-Fluoro-4,5-dimethoxybenzaldehyde

生成物 1

HCID 57448188Methyl 2-(2-fluoro-4,5-dimethoxyphenyl)-2-hydroxyacetate収率 44%

実験手順

7A (1.05 g, 44%) was prepared in 2 steps from 2-fluoro-4,5-dimethoxybenzaldehyde following procedures analogous to the preparation of 6B. LC-MS: 267.11 (M+Na)+.

出典と根拠

ORDレコード: ord-5fc53b28eedb4ff7981e5863cad4b791
出典データセット: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08044242B2

反応ノート

読み込み中…