Bromine → 2-Bromo-1-[2-(trifluoromethyl)phenyl]ethan-1-one

HRID 1667651ノート

反応式

HRID 1667651 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9](=[O:11])[CH3:10].[Br:14]Br>ClCCl>[Br:14][CH2:10][C:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:12])([F:13])[F:1])=[O:11]

参加物

4

反応物 2

HCID 24408BromineHCID 870952'-(Trifluoromethyl)acetophenone

生成物 1

HCID 27784302-Bromo-1-[2-(trifluoromethyl)phenyl]ethan-1-one収率 92.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 20.00 g (0.11 mole) of 2′-(trifluoromethyl)acetophenone in 200 mL of dichloromethane was added 5.5 mL (0.11 mole) of bromine over 90 minutes. A stream of nitrogen was bubbled through the reaction mixture for 15 minutes. The mixture solvent was removed under reduced pressure. The residue was dissolved with ethanol, and then concentrated under reduced pressure to give 27.25 g of 2-bromo-1-(2-trifluoromethyl-phenyl)-ethanone as a yellow oil, which was used in the next step without further purification.

後処理

  1. customA stream of nitrogen was bubbled through the reaction mixture for 15 minutes
  2. customThe mixture solvent was removed under reduced pressure
  3. dissolutionThe residue was dissolved with ethanol
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-0b0a9f6db9024e3eb37d062e137f3e1f
出典データセット
uspto-grants-2011_10
特許番号
US08044213B2

反応ノート

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