Sulfuric Acid → 4-(4-trifluoromethyl-phenyl)-3H-thiazol-2-one
反応式
[S:1]([CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=1)=O)[C:2]#[N:3].S(=O)(=O)(O)[OH:18]>C(O)(=O)C>[F:14][C:13]([F:16])([F:15])[C:10]1[CH:11]=[CH:12][C:7]([C:5]2[NH:3][C:2](=[O:18])[S:1][CH:4]=2)=[CH:8][CH:9]=1参加物
4
実験手順
A mixture of 22.52 g (91.8 mmole) of 2-thiocyanato-1-(4-trifluoromethyl-phenyl)-ethanone 9 mL of 50% aqueous sulfuric acid and 45 mL of acetic acid was heated at reflux for 1.5 hours. The mixture was cooled, poured into 500 mL of ice water and stirred for 30 minutes. The solid was collected by filtration, washing with water, to give 21.33 g of 4-(4-trifluoromethyl-phenyl)-3H-thiazol-2-one as a tan solid.
後処理
- temperaturewas heated
- temperatureat reflux for 1.5 hours
- temperatureThe mixture was cooled
- filtrationThe solid was collected by filtration
- washwashing with water
出典と根拠
- ORDレコード
- ord-73bbd9e4e1594d838e98bb1826b0a963
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08044213B2
反応ノート
読み込み中…