化工社化工社 化学情報印刷レポート · 研究参考用
Water → Bactroban
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Mupirocin | HCID 446596 | — |
| 反応物 | Calciumoxide | HCID 6850728 | — |
| 溶媒 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | Bactroban | HCID 6435927 | 87.7% |
反応手順
Pseudomonic acid (10.01 g, 20 mmole) was dissolved in a mixture of methanol/water (50 ml and 36 ml). Calcium oxide (0.78 g, 14 mmole) was added portionwise to the mixture and was stirred for 1 h. The solution was filtered, and the methanol was evaporated from the filtrate at reduced pressure to give a final volume of 30 ml. Water (20 ml) was added to the solution. Then the solution was freeze dried to obtain 9.11 grams of product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737177B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-60044640ac4f49cfa96a7c565ef0c340 |
| 出典メモ | uspto-grants-2010_06 |