Diethyl Ether → 6-Iodoimidazo[1,2-B]pyridazin-2-amine
反応式
[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH:11]C(=O)OC(C)(C)C)[N:10]=2)[N:7]=1.Cl.C(OCC)(=O)C.C(OCC)C>C(OCC)(=O)C>[I:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH2:11])[N:10]=2)[N:7]=1参加物
5
実験手順
To a suspension of tert-butyl (6-iodoimidazo[1,2-b]pyridazin-2-yl)carbamate (10.2 g, 28.3 mmol) in ethyl acetate (50 mL) was added 4N hydrochloric acid/ethyl acetate (75 mL), and the mixture was stirred at room temperature for 4 hr. Diethyl ether (200 mL) was added to the reaction mixture, and the precipitate was filtrated. After washing with saturated aqueous sodium hydrogencarbonate solution, the filtrate was washed with water, acetonitrile and diethyl ether to give the title compound (4.9 g, 67%) as a green powder.
後処理
- filtrationthe precipitate was filtrated
- washAfter washing with saturated aqueous sodium hydrogencarbonate solution
- washthe filtrate was washed with water, acetonitrile and diethyl ether
出典と根拠
- ORDレコード
- ord-7c6ce4cf91e8445499f27372fb85391c
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08044049B2
反応ノート
読み込み中…