3-[(3-Chloropropyl)thio]-4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazole → 2-Ethyl-7-(3-{[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

HRID 1668612ノート

反応式

HRID 1668612 の反応式
[CH2:1]([C:3]1[O:4][C:5]2[C:15]([N:16]=1)=[CH:14][C:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][C:7]=1[CH:6]=2)[CH3:2].[Cl:17][CH2:18][CH2:19][CH2:20][S:21][C:22]1[N:26]([CH3:27])[C:25]([C:28]2[O:32][CH:31]=[N:30][C:29]=2[CH3:33])=[N:24][N:23]=1>>[ClH:17].[CH2:1]([C:3]1[O:4][C:5]2[C:15]([N:16]=1)=[CH:14][C:8]1[CH2:9][CH2:10][N:11]([CH2:18][CH2:19][CH2:20][S:21][C:22]3[N:26]([CH3:27])[C:25]([C:28]4[O:32][CH:31]=[N:30][C:29]=4[CH3:33])=[N:24][N:23]=3)[CH2:12][CH2:13][C:7]=1[CH:6]=2)[CH3:2]

参加物

3

反応物 2

HCID 446279943-[(3-Chloropropyl)thio]-4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazoleHCID 591504912-ethyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine

生成物 1

HCID 673592832-Ethyl-7-(3-{[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

実験手順

The title compound was prepared in analogy to General Procedure 1 rom 2-ethyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine (0.28 mmol) and 3-[(3-chloropropyl)thio]-4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazole and was obtained as a faint yellow slightly hygroscopic solid (0.07 mmol).

出典と根拠

ORDレコード
ord-7efb65edd6dd46968ef3c943c436ec4c
出典データセット
uspto-grants-2011_08
特許番号
US07989444B2

反応ノート

読み込み中…