3-[(3-Chloropropyl)thio]-4-methyl-5-[4-(trifluoromethyl)phenyl]-4H-1,2,4-triazole → 3-methyl-7-[3-({4-methyl-5-[4-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}thio)propyl]-6,7,8,9-tetrahydro-5H-isoxazolo[4,5-h][3]benzazepine hydrochloride

HRID 1668615ノート

反応式

HRID 1668615 の反応式
[CH3:1][C:2]1[C:15]2[C:5](=[CH:6][C:7]3[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][C:8]=3[CH:14]=2)[O:4][N:3]=1.[Cl:16][CH2:17][CH2:18][CH2:19][S:20][C:21]1[N:25]([CH3:26])[C:24]([C:27]2[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=2)=[N:23][N:22]=1>>[ClH:16].[CH3:1][C:2]1[C:15]2[C:5](=[CH:6][C:7]3[CH2:13][CH2:12][N:11]([CH2:17][CH2:18][CH2:19][S:20][C:21]4[N:25]([CH3:26])[C:24]([C:27]5[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:34])[F:35])=[CH:29][CH:28]=5)=[N:23][N:22]=4)[CH2:10][CH2:9][C:8]=3[CH:14]=2)[O:4][N:3]=1

参加物

3

反応物 2

HCID 591505083-[(3-Chloropropyl)thio]-4-methyl-5-[4-(trifluoromethyl)phenyl]-4H-1,2,4-triazoleHCID 591505103-methyl-6,7,8,9-tetrahydro-5H-isoxazolo[4,5-h][3]benzazepine

生成物 1

HCID 673587893-methyl-7-[3-({4-methyl-5-[4-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}thio)propyl]-6,7,8,9-tetrahydro-5H-isoxazolo[4,5-h][3]benzazepine hydrochloride

実験手順

The title compound was prepared in analogy to General Procedure 1 from 3-methyl-6,7,8,9-tetrahydro-5H-isoxazolo[4,5-h][3]benzazepine (0.12 mmol) and 3-[(3-chloropropyl)thio]-4-methyl-5-[4-(trifluoromethyl)phenyl]-4H-1,2,4-triazole (0.14 mmol) and was obtained as a faint yellow slightly hygroscopic solid (0.01 mmol).

出典と根拠

ORDレコード
ord-4e058e8f50124026a5022463a8c40cec
出典データセット
uspto-grants-2011_08
特許番号
US07989444B2

反応ノート

読み込み中…