関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2,6-Dichloro-3-nitropyridine | HCID 85239 | — |
| 反応物 | Benzenemethanamine, 2,6-dichloro- | HCID 485432 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | n-(2,6-Dichlorobenzyl)-6-chloro-3-nitropyridin-2-amine | HCID 59705189 | 29.7% |
反応手順
To a mixture of 2,6-dichloro-3-nitropyridine (1.0 g, 5.18 mmol) and potassium carbonate (848 mg, 6.14 mmol) in 15 mL MeCN was added 2,6-dichlorobenzylamine (0.63 mL, 5.18 mmol) at 0° C. The reaction mixture was stirred for one hour at 0° C. and then for 10 hours at room temperature. The organic solvent was evaporated and the residue was purified by silica gel chromatography (EtOAc:Hex=1:10) giving 16 [511 mg].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07989459B2 |
|---|
| 出典データセット | uspto-grants-2011_08 |
|---|
| ORD ID | ord-b299745f821a4990843ff64349482d6f |
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| 出典メモ | uspto-grants-2011_08 |
|---|
