Glyoxylic Acid → HCID 10012697、化合物
反応式
[C:1]1(=[O:10])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[C:11]([OH:15])(=[O:14])[CH:12]=O>O1CCOCC1>[O:10]=[C:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]/[C:2]/1=[CH:12]\[C:11]([OH:15])=[O:14]参加物
4
実験手順
A mixture of 1-indanone (145) (25 g, 190 mmol), glyoxylic acid (50% aqueous solution, 70 g, 470 mmol), and CH2SO4 (6.25 mL) in dioxane (25 mL) were stirred at reflux temperature for 4 h. The mixture was cooled, the product filtered off, washed with water and dried to give acid 146 (32.8 g, 92%) as a white solid: mp 201-203° C. [lit. (Nagasawa et al., Japanese Patent 04338358, 1992) 205-206° C.]; 1H NMR [(CD3)2SO] δ 12.00 (br s, 1H, OH), 7.73-7.80 (m, 2H, H-5, H-7), 7.68 (br d, J=7.7 Hz, 1H, H-4), 7.49 (t, J=7.9 Hz, 1H, H-6), 6.55 (t, J=2.4 Hz, 1H, CHCO2), 4.08 (d, J=1.8 Hz, 2H, H-3).
後処理
- temperatureat reflux temperature for 4 h
- temperatureThe mixture was cooled
- filtrationthe product filtered off
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-2a0a0156d5b64aacb0ce4b1cea1a68f7
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07989451B2
反応ノート
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