HCID 57447694、化合物 → 2-(3-Methoxy-piperidin-1-yl)-ethylamine
反応式
[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([CH2:9][C:10]#[N:11])[CH2:4]1>[Ni].CCO>[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH2:6][N:5]([CH2:9][CH2:10][NH2:11])[CH2:4]1参加物
4
実験手順
A mixture of nitrile 282 (3.5 g, 22.7 mmol) and Raney Nickel (50% w/w suspension in water, 8 g) in EtOH (100 mL) and cNH3 (10 mL) was stirred under H2 (60 psi) for 22 h. The mixture was filtered through Celite, the solid washed with EtOH (60 mL) and the solvent evaporated to give diamine 283 as a crude colourless oil (3.48 g, 97%) which was used without further purification: HRMS (FAB+) calcd for C8H19N2O (MH+) m/z 159.14974, found 159.14976.
後処理
- filtrationThe mixture was filtered through Celite
- washthe solid washed with EtOH (60 mL)
- customthe solvent evaporated
出典と根拠
- ORDレコード
- ord-50fe84e1f9884855b5914cd94b0d29a5
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07989451B2
反応ノート
読み込み中…