(4-Methoxy-1-piperidinyl)acetonitrile → 2-(4-Methoxy-piperidin-1-yl)-ethylamine
反応式
[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][N:6]([CH2:9][C:10]#[N:11])[CH2:5][CH2:4]1>[Ni].CCO>[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][N:6]([CH2:9][CH2:10][NH2:11])[CH2:5][CH2:4]1参加物
4
実験手順
A mixture of nitrile 287 (10.25 g, 66.5 mmol) and Raney Nickel (50% w/w in water, ca. 10 mL) in EtOH (150 mL) and cNH3 (10 mL) was stirred under H2 (60 psi) for 16 h. The mixture was filtered through Celite, washed with EtOH (3×10 mL) and the solvent evaporated to give crude diamine 288 as an oil which was used directly.
後処理
- filtrationThe mixture was filtered through Celite
- washwashed with EtOH (3×10 mL)
- customthe solvent evaporated
出典と根拠
- ORDレコード
- ord-29404ad964c04ee0b72b23aa1102f881
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07989451B2
反応ノート
読み込み中…