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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
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tert-butyl {2-[[(7R)-14-cyclohexyl-11-[({[(2,2-dimethoxyethyl)(methyl)amino]-sulfonyl}amino)carbonyl]-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocin-7-yl](methyl)amino]ethyl}methylcarbamate → (7R)-14-cyclohexyl-7-{methyl[2-(methylamino)ethyl]amino}-N-{[methyl(2-oxoethyl)amino]sulfonyl}-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxamide

HRID 1669421
ノート
印刷プレビュー

反応式

HRID 1669421 の反応式
[CH:1]1([C:7]2[C:8]3[CH:9]=[CH:10][C:11]([C:47]([NH:49][S:50]([N:53]([CH2:55][CH:56](OC)[O:57]C)[CH3:54])(=[O:52])=[O:51])=[O:48])=[CH:12][C:13]=3[N:14]3[C:21]=2[C:20]2[CH:22]=[CH:23][C:24]([O:26][CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=4)=[CH:25][C:19]=2[O:18][CH2:17][C@H:16]([N:34]([CH3:46])[CH2:35][CH2:36][N:37](C)[C:38](=O)OC(C)(C)C)[CH2:15]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>C(Cl)Cl.O.C(O)(C(F)(F)F)=O>[CH:1]1([C:7]2[C:8]3[CH:9]=[CH:10][C:11]([C:47]([NH:49][S:50]([N:53]([CH3:54])[CH2:55][CH:56]=[O:57])(=[O:51])=[O:52])=[O:48])=[CH:12][C:13]=3[N:14]3[C:21]=2[C:20]2[CH:22]=[CH:23][C:24]([O:26][CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=4)=[CH:25][C:19]=2[O:18][CH2:17][C@H:16]([N:34]([CH3:46])[CH2:35][CH2:36][NH:37][CH3:38])[CH2:15]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

3

反応物 1

HCID 67344800tert-butyl {2-[[(7R)-14-cyclohexyl-11-[({[(2,2-dimethoxyethyl)(methyl)amino]-sulfonyl}amino)carbonyl]-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocin-7-yl](methyl)amino]ethyl}methylcarbamate

生成物 1

HCID 86627898(7R)-14-cyclohexyl-7-{methyl[2-(methylamino)ethyl]amino}-N-{[methyl(2-oxoethyl)amino]sulfonyl}-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxamide

試薬・触媒・溶媒 1

HCID 18672661TFA dichloromethane water
溶媒

反応条件

温度
40 °C

実験手順

tert-butyl {2-[[(7R)-14-cyclohexyl-11-[({[(2,2-dimethoxyethyl)(methyl)amino]-sulfonyl}amino)carbonyl]-3-(pyridin-2-ylmethoxy)-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocin-7-yl](methyl)amino]ethyl}methylcarbamate was dissolved in DCM/H2O/TFA (8:1:3, 15 mM). The mixture was warmed to 40° C. After 30 min all volatiles were evaporated in vacuo and the residual material was coevaporated twice with toluene. The remaining yellow oil was used in the next reaction without further purification.

後処理

  1. customAfter 30 min all volatiles were evaporated in vacuo
  2. customThe remaining yellow oil was used in the next reaction without further purification

出典と根拠

ORDレコード
ord-8d02a564d8da4eaa873019bd7fc119fe
出典データセット
uspto-grants-2011_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07989438B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート