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1-Benzyl-4-iodobenzene → (R)-[4-(4-Benzyl-phenoxy)-phenyl]-tert-butoxycarbonylamino acetic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Benzyl-4-iodobenzene | HCID 2759364 | — |
| 反応物 | Methyl (2R)-2-{[(tert-butoxy)carbonyl]amino}-2-(4-hydroxyphenyl)acetate | HCID 10934864 | — |
| 生成物 | (R)-[4-(4-Benzyl-phenoxy)-phenyl]-tert-butoxycarbonylamino acetic acid methyl ester | HCID 67352764 | 50% |
反応手順
The title compound was prepared from the product from step 1 (1.3 g, 4.6 mmol) and 4-iododiphenylmethane (2.0 g, 6.9 mmol) using the Step 4 procedure of example 1 with 50% yield (1.1 g). 1HNMR (CDCl3) 1.43 (s, 9H), 3.73 (s, 3H), 3.97 (s, 2H), 5.29 (m, 1H), 5.50 (m, 1H), 6.94 (m, 4H), 7.15 (d, J=6.8 Hz, 2H), 7.20 (m, 3H), 7.30 (m, 4H), MS m/z 448 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07989480B2 |
| 出典データセット | uspto-grants-2011_08 |
| ORD ID | ord-1bff4306ab284ae98951411437d82cc4 |
| 出典メモ | uspto-grants-2011_08 |