Water → HCID 67334872、化合物

HRID 1669841ノート

反応式

HRID 1669841 の反応式
C1([C:7]2[N:11]([C:12]3[CH:17]=[CH:16][C:15]([O:18][C:19]([F:22])([F:21])[F:20])=[CH:14][CH:13]=3)[N:10]=[CH:9][C:8]=2[CH2:23][C:24]2[CH:31]=[CH:30][C:27]([C:28]#N)=[CH:26][CH:25]=2)CCCCC1.[OH2:32].[OH-:33].[K+]>C(O)C>[CH2:12]1[CH2:17][CH:16]([CH:23]([C:24]2[CH:31]=[CH:30][C:27]([C:28]([OH:33])=[O:32])=[CH:26][CH:25]=2)[C:8]2[CH:9]=[N:10][N:11]([C:12]3[CH:13]=[CH:14][C:15]([O:18][C:19]([F:22])([F:20])[F:21])=[CH:16][CH:17]=3)[CH:7]=2)[CH2:15][CH2:14][CH2:13]1

参加物

5

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 67335137HCID 67335137、化合物

生成物 1

HCID 67334872HCID 67334872、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a hot solution of 0.73 g 4-({5-cyclohexyl-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl}methyl)benzonitrile From Step E above in 15 mL ethanol and 6 mL water was added 1.11 g potassium hydroxide. The resulting solution was refluxed under nitrogen over night. The solvents were removed under reduced pressure. The residue was re-suspended in 10 mL water and acidified with 9.0 mL 2 N HCl. The resulting solid was filtered, washed with water, and dried to give the title compound as a white solid. 1H NMR (CD3OD, 500 MHz) δ 7.95 (d, J=8.2 Hz, 2H), 7.48˜7.50 (m, 2H), 7.45 (d, J=8.6 Hz, 2H), 7.36 (s, 1H), 7.32 (d, J=8.2 Hz, 2H), 4.06 (s, 2H), 2.66 (tt, J=3.0 & 12.7 Hz, 1H), 1.69˜1.73 (m, 4H), 1.53˜1.64 (m, 3H), 1.09˜1.19 (m, 3H). LC-MS: 2.29 min. (M+H=445.2).

後処理

  1. temperatureThe resulting solution was refluxed under nitrogen over night
  2. customThe solvents were removed under reduced pressure
  3. filtrationThe resulting solid was filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-2622226468db40eda3d4d3aa1763db79
出典データセット
uspto-grants-2011_08
特許番号
US07989475B2

反応ノート

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