Iodine → 2-Bromo-8-iododibenzofuran

HRID 1669919

反応式

HRID 1669919 の反応式
[Br:1][C:2]1[CH:14]=[CH:13][C:5]2[O:6][C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[C:4]=2[CH:3]=1.[I:15](O)(O)(O)(O)(O)=O.II.S(=O)(=O)(O)O>O.C(O)(=O)C>[Br:1][C:2]1[CH:14]=[CH:13][C:5]2[O:6][C:7]3[CH:12]=[CH:11][C:10]([I:15])=[CH:9][C:8]=3[C:4]=2[CH:3]=1

参加物

7

反応物 4

HCID 807IodineHCID 1118Sulfuric AcidHCID 68562-BromodibenzofuranHCID 25289Orthoperiodic acid

生成物 1

HCID 673359322-Bromo-8-iododibenzofuran

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒2 回

反応条件

温度
70 °C

実験手順

2-Bromodibenzofuran (2.5 g, 10.1 mmol), orthoperiodic acid (0.49 g, 2.15 mmol), iodine (1.02 g, 4.02 mmol), sulfuric acid, H2O (2 ml) and acetic acid (10 ml) are put into a reaction vessel and the mixture is stirred at 70° C. for 3 hours. After cooling to room temperature the reaction mixture is poured into water and filtered. The white solid is washed by methanol and the desired product is obtained (1.92 g, 51%).

後処理

  1. temperatureAfter cooling to room temperature the reaction mixture
  2. filtrationfiltered
  3. washThe white solid is washed by methanol

出典と根拠

ORDレコード
ord-9852295a50264bfe8ffa77266eda349a
出典データセット
uspto-grants-2011_08
特許番号
US07989644B2

関連ノート

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