Acetic Anhydride → 4-[3-{6-[3-(4-Acetyl-piperazine-1-carbonyl)-5-benzo[1,3]dioxol-5-yl-phenoxy]-hexyl}-2-(2-carboxy-ethyl)-phenoxy]-butyric Acid

HRID 1670078ノート

反応式

HRID 1670078 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:11]=[C:12]([CH:38]=[C:39]([C:41]([N:43]4[CH2:48][CH2:47][NH:46][CH2:45][CH2:44]4)=[O:42])[CH:40]=3)[O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]3[C:21]([CH2:33][CH2:34][C:35]([OH:37])=[O:36])=[C:22]([CH:30]=[CH:31][CH:32]=3)[O:23][CH2:24][CH2:25][CH2:26][C:27]([OH:29])=[O:28])=[CH:9][C:4]=2[O:3][CH2:2]1.[C:49](OC(=O)C)(=[O:51])[CH3:50].C(N(CC)CC)C>ClCCl.C(OCC)(=O)C>[C:49]([N:46]1[CH2:45][CH2:44][N:43]([C:41]([C:39]2[CH:38]=[C:12]([CH:11]=[C:10]([C:8]3[CH:7]=[CH:6][C:5]4[O:1][CH2:2][O:3][C:4]=4[CH:9]=3)[CH:40]=2)[O:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20]2[C:21]([CH2:33][CH2:34][C:35]([OH:37])=[O:36])=[C:22]([CH:30]=[CH:31][CH:32]=2)[O:23][CH2:24][CH2:25][CH2:26][C:27]([OH:29])=[O:28])=[O:42])[CH2:48][CH2:47]1)(=[O:51])[CH3:50]

参加物

6

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 426303214-[3-{6-[3-Benzo[1,3]dioxol-5-yl-5-(piperazine-1-carbonyl)-phenoxy]-hexyl}-2-(2-carboxy-ethyl)-phenoxy]-butyric acid

生成物 1

HCID 673390604-[3-{6-[3-(4-Acetyl-piperazine-1-carbonyl)-5-benzo[1,3]dioxol-5-yl-phenoxy]-hexyl}-2-(2-carboxy-ethyl)-phenoxy]-butyric Acid

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

4-[3-{6-[3-Benzo[1,3]dioxol-5-yl-5-(piperazine-1-carbonyl)-phenoxy]-hexyl}-2-(2-carboxy-ethyl)-phenoxy]-butyric acid (0.29 mmol), acetic anhydride (1.2 eq.), triethylamine (3 eq.) were combined in dichloromethane (2 mL) and stirred overnight. Then the reaction mixture was diluted with ethyl acetate, washed with water and dried over anhydrous sodium sulfate. The organic extract was concentrated under reduced pressure and purified by reverse-phase HPLC to yield the title compound.

後処理

  1. washwashed with water
  2. dry with materialdried over anhydrous sodium sulfate
  3. extractionThe organic extract
  4. concentrationwas concentrated under reduced pressure
  5. custompurified by reverse-phase HPLC

出典と根拠

ORDレコード
ord-56601493fce84ec584e5a8823c8abad4
出典データセット
uspto-grants-2011_08
特許番号
US07989454B2

反応ノート

読み込み中…