Hydrochloric Acid → 4-(4-Amino-3-fluorophenoxy)pyridin-2-amine

HRID 1670301ノート

反応式

HRID 1670301 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([O:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15]C(=O)C(C)(C)C)=[C:11]([F:22])[CH:10]=2)[CH:5]=[CH:4][N:3]=1.Cl>CO>[NH2:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH2:1])[CH:7]=2)=[CH:10][C:11]=1[F:22]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 59852964N-(4-(2-aminopyridin-4-yloxy)-2-fluorophenyl)pivalamide

生成物 1

HCID 71470884-(4-Amino-3-fluorophenoxy)pyridin-2-amine収率 54%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of N-(4-(2-aminopyridin-4-yloxy)-2-fluorophenyl)pivalamide (70 mg, 0.23 mmol) in 3 mL of MeOH was added 2 mL of 6 N HCl. The mixture was then heated at reflux for 48 h. After cooling down, the solvent was removed under reduced pressure and the residue was purified by solid extraction (Waters Oasis MCX extraction cartridge) to give 4-(4-amino-3-fluorophenoxy)pyridin-2-amine (27 mg, 54% yield). MS (ESI+): m/z 220.21 (M+H)+.

後処理

  1. temperatureThe mixture was then heated
  2. temperatureat reflux for 48 h
  3. temperatureAfter cooling down
  4. customthe solvent was removed under reduced pressure
  5. customthe residue was purified by solid extraction (Waters Oasis MCX extraction cartridge)

出典と根拠

ORDレコード
ord-e5ecf470d9584b09b020e63669641102
出典データセット
uspto-grants-2011_08
特許番号
US07989477B2

反応ノート

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