Benzyl Bromide → Benzyl 2-(3-(benzyloxy)phenyl)acetate

HRID 1670339ノート

反応式

HRID 1670339 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.C([O-])([O-])=O.[K+].[K+].[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CN(C=O)C>[CH2:18]([O:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH2:8][C:4]2[CH:5]=[CH:6][CH:7]=[CH:2][CH:3]=2)=[O:10])[CH:5]=[CH:6][CH:7]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 121223'-Hydroxyphenylacetic acid

生成物 1

HCID 15470856Benzyl 2-(3-(benzyloxy)phenyl)acetate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 3-hydroxyphenylacetic acid (Acros, 3.04 g, 20 mmol) in 20 mL of DMF were added K2CO3 (6.90 g, 50 mmol) and benzyl bromide (4.75 mL, 40 mmol) at room temperature. The reaction mixture was stirred for 24 h. The suspension was filtered and washed with diethyl ether. The filtrate was then washed with brine and dried over MgSO4. Filtration, followed by concentration, provided the crude benzyl 2-(3-(benzyloxy)phenyl)acetate which was used in the next step. MS (ESI+) m/z 355 (M+Na)+.

後処理

  1. filtrationThe suspension was filtered
  2. washwashed with diethyl ether
  3. washThe filtrate was then washed with brine
  4. dry with materialdried over MgSO4
  5. filtrationFiltration
  6. concentrationfollowed by concentration

出典と根拠

ORDレコード
ord-c11fc04207484e4e9fc6b7868895690d
出典データセット
uspto-grants-2011_08
特許番号
US07989477B2

反応ノート

読み込み中…