Water → N-(tert-butoxycarbonyl)-O-(3-nitrobiphenyl-2-yl)-L-serine

HRID 1670430ノート

反応式

HRID 1670430 の反応式
[C:1]1(B(O)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(=O)([O-])[O-].[Cs+].[Cs+].O.Br[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([N+:24]([O-:26])=[O:25])[C:19]=1[O:27][CH2:28][C@@H:29]([C:38]([OH:40])=[O:39])[NH:30][C:31]([O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:32]>C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].O1CCOCC1>[C:34]([O:33][C:31]([NH:30][C@H:29]([C:38]([OH:40])=[O:39])[CH2:28][O:27][C:19]1[C:20]([N+:24]([O-:26])=[O:25])=[CH:21][CH:22]=[CH:23][C:18]=1[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[O:32])([CH3:37])([CH3:36])[CH3:35]

参加物

7

反応物 4

HCID 962WaterHCID 10796Cesium carbonateHCID 66827Phenylboronic AcidHCID 67328353O-(2-bromo-6-nitrophenyl)-N-(tert-butoxycarbonyl)-L-serine

生成物 1

HCID 67328913N-(tert-butoxycarbonyl)-O-(3-nitrobiphenyl-2-yl)-L-serine

試薬・触媒・溶媒 2

HCID 178418228Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)触媒HCID 312751,4-Dioxane溶媒

反応条件

温度
100 °C

実験手順

331 mg of phenylboronic acid (2.72 mmol), 50.3 mg of 1,1′-bis(diphenylphosphino)ferrocenepalladium chloride (C35H30Cl4FeP2Pd, MW 816.65, 0.025 mmol) and 3.22 g of caesium carbonate (9.87 mmol) are introduced into a 100 mL round-bottomed flask, with stirring and under an argon atmosphere, containing 16 mL of water, 5 mL of dioxane and 1 g of 34 (2.47 mmol). The medium is heated at 100° C., with stirring, for 1 h. The dioxane is concentrated and the aqueous phase is acidified to pH 2-3, extracted twice with 50 ml of AcOEt. The combined organic phases are dried over MgSO4, filtered and evaporated to dryness. The crude product is chromatographed on a silica cartridge (150 g, eluent CH2Cl2/MeOH, in an MeOH gradient: 1 to 5%). 500 mg of expected product 35 (yellow oil) are recovered.

後処理

  1. stirringwith stirring, for 1 h
  2. concentrationThe dioxane is concentrated
  3. extractionextracted twice with 50 ml of AcOEt
  4. dry with materialThe combined organic phases are dried over MgSO4
  5. filtrationfiltered
  6. customevaporated to dryness
  7. customThe crude product is chromatographed on a silica cartridge (150 g, eluent CH2Cl2/MeOH
  8. custom500 mg of expected product 35 (yellow oil) are recovered

出典と根拠

ORDレコード
ord-bc11571423cb4dd4911ebdfe2f61ff3e
出典データセット
uspto-grants-2011_08
特許番号
US07994161B2

反応ノート

読み込み中…