Water → (4R,4aS,7R,7aR)-4-[(1R)-1,2-dihydroxyethyl]-7-ethoxy-2,2-dimethyltetrahydro-6H-furo[3,2-d][1,3]dioxin-6-one
反応式
CC1(C)[O:6][C@@H:5]([C@H:7]2[O:12][C:11]([CH3:14])([CH3:13])[O:10][C@H:9]3[C@@H:15]([O:19][CH2:20][CH3:21])[C:16](=[O:18])[O:17][C@@H:8]23)[CH2:4][O:3]1.O>C(O)(=O)C>[OH:6][C@@H:5]([C@H:7]1[O:12][C:11]([CH3:14])([CH3:13])[O:10][C@H:9]2[C@@H:15]([O:19][CH2:20][CH3:21])[C:16](=[O:18])[O:17][C@@H:8]12)[CH2:4][OH:3]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
2.62 g of 48 (8.28 mmol) are introduced into a 100 mL three-necked flask containing 16 mL of water and 16 mL of acetic acid. The medium is stirred for 24 h at RT and then the reaction medium is concentrated under vacuum. The residues are disintegrated with 25 mL of isopropyl ether, filtered and dried under vacuum. 2.15 g of expected product 49 (white solid) are obtained.