Hydrogen chloride-ethyl acetate → 1-(Thiophen-2-YL)piperazine hydrochloride
反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:19].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:19].[S:15]1[CH:16]=[CH:17][CH:18]=[C:14]1[N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1参加物
4
実験手順
4-(2-Thienyl)piperazine-1-carboxylic acid tert-butyl ester (700 mg) was dissolved in ethyl acetate (4 ml), a 4N hydrochloric acid-ethyl acetate solution (4 ml) was added, and the mixture was stirred at room temperature for 1.5 hr. The precipitated solid was collected by filtration, washed with ethyl acetate and dried to give 1-(2-thienyl)piperazine hydrochloride (532 mg, yield 98%).
後処理
- filtrationThe precipitated solid was collected by filtration
- washwashed with ethyl acetate
- customdried
出典と根拠
- ORDレコード
- ord-277e2fd057094455b0f702445eeefb32
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07994196B2
反応ノート
読み込み中…