Hydrogen chloride-ethyl acetate → 1-(2-Thienyl)piperazine hydrochloride

HRID 1670744

反応式

HRID 1670744 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:19].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:19].[S:15]1[CH:16]=[CH:17][CH:18]=[C:14]1[N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 673439001-Boc-4-(2-thienyl)piperazine

生成物 1

HCID 231498111-(2-Thienyl)piperazine hydrochloride収率 98%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

4-(2-Thienyl)piperazine-1-carboxylic acid tert-butyl ester (700 mg) was dissolved in ethyl acetate (4 ml), a 4N hydrochloric acid-ethyl acetate solution (4 ml) was added, and the mixture was stirred at room temperature for 1.5 hr. The precipitated solid was collected by filtration, washed with ethyl acetate and dried to give 1-(2-thienyl)piperazine hydrochloride (532 mg, yield 98%).

後処理

  1. filtrationThe precipitated solid was collected by filtration
  2. washwashed with ethyl acetate
  3. customdried

出典と根拠

ORDレコード
ord-277e2fd057094455b0f702445eeefb32
出典データセット
uspto-grants-2011_08
特許番号
US07994196B2

関連ノート

読み込み中…