Hydrochloric Acid → N-Methoxy-N-methylbenzofuran-5-carboxamide
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10](Cl)=[O:11])=[CH:9][C:4]=2[CH:3]=[CH:2]1.[CH3:13][NH:14][O:15][CH3:16].Cl.C(N(CC)CC)C>C(Cl)Cl>[CH3:16][O:15][N:14]([CH3:13])[C:10]([C:8]1[CH:7]=[CH:6][C:5]2[O:1][CH:2]=[CH:3][C:4]=2[CH:9]=1)=[O:11]参加物
6
実験手順
Benzofuran-5-carbonyl chloride (1 g, 5.54 mmol) in dry DCM (40 ml) is treated with N,O-dimethylhydroxylamine.HCl (0.594 g, 6.09 mmol) followed by triethylamine (1.930 ml, 13.84 mmol). After stirring at RT overnight, the mixture is diluted with DCM and washed with H2O, 1M HCl, 1M NaOH, brine, dried (MgSO4) and evaporated down to give a brown oil which is used without further purification; MS: m/z 206.1 [M+H]+
後処理
- washwashed with H2O, 1M HCl, 1M NaOH, brine
- dry with materialdried (MgSO4)
- customevaporated down
- customto give a brown oil which
- customis used without further purification
出典と根拠
- ORDレコード
- ord-23367186aafe462faa1f35bddd627338
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07994203B2
反応ノート
読み込み中…