Ammonium Chloride → 1-(2-Methoxy-4-methyl-phenyl)-propan-1-ol
反応式
[CH3:1][O:2][C:3]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:4]=1[CH:5]=[O:6].[CH3:12][CH2:13][Mg+].[Br-].[Cl-].[NH4+]>C(OCC)C>[CH3:1][O:2][C:3]1[CH:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:4]=1[CH:5]([OH:6])[CH2:12][CH3:13]参加物
5
実験手順
To a stirring solution of 2-methoxy-4-methylbenzaldehyde (1 g, 6.66 mmol) in diethyl ether (35 ml) at 0° C. is added EtMgBr (2.220 ml, 6.66 mmol). The mixture is stirred for 2 hours and then added to sat ammonium chloride solution. The mixture is extracted with ethyl acetate and the combined organic portions are washed with NaHCO3, water and brine dried (MgSO4) and reducing under vacuum to yield the title product as a clear oil. 1H NMR (400 MHz, CDCl3) δ 7.18 (d, 1H), 6.78 (d, 1H), 6.72 (s, 1H), 4.77 (t, 1H), 3.85 (s, 3H), 2.37 (s, 3H), 1.83 (m, 2H), 0.96 (t, 3H).
後処理
- additionadded
- extractionThe mixture is extracted with ethyl acetate
- washthe combined organic portions are washed with NaHCO3, water and brine
- dry with materialdried (MgSO4)
出典と根拠
- ORDレコード
- ord-0978c5cdbfdb4018beb525bac7e36a37
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07994203B2
反応ノート
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