Methyl pyrimidine-4-carboxylate → 4-Pyrimidinecarboxylic acid

HRID 1671469ノート

反応式

HRID 1671469 の反応式
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][N:6]=1)=[O:4].BrC1C(C(O)=S)=NC(C)=NC=1>[Ni]>[N:8]1[CH:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 254248Methyl pyrimidine-4-carboxylateHCID 178432654HCID 178432654、化合物

生成物 1

HCID 1693064-Pyrimidinecarboxylic acid

試薬・触媒・溶媒 1

HCID 935Nickel触媒

実験手順

While J. Org. Chem., 30, 2398 (1965) describes that methylpyrimidine-4-carboxylate can be synthesized by treating 5-bromo-2-methylthiopyrimidine-4-carboxylic acid with Raney-nickel, as described in J. Chem. Soc., 1953, 3129, to give pyrimidine-4-carboxylic acid, and heating the obtained compound in methanol in the presence of concentrated hydrochloric acid. This method is problematic in the availability of the starting materials.

後処理

  1. customcan be synthesized

出典と根拠

ORDレコード
ord-d5a16c132df441b6816d964009780896
出典データセット
uspto-grants-2011_08
特許番号
US07994315B2

反応ノート

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