4-Chlororesorcinol → 6-Chloro-7-hydroxy coumarin
反応式
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([OH:6])=[CH:4][C:3]=1[OH:9].[CH2:10]([CH:17](C(C)=O)[C:18](OCC)=[O:19])C1C=CC=CC=1>OS(O)(=O)=O>[Cl:1][C:2]1[CH:8]=[C:7]2[C:5](=[CH:4][C:3]=1[OH:9])[O:6][C:18](=[O:19])[CH:17]=[CH:10]2参加物
4
実験手順
4-Chlororesorcinol (26.25 g, 0.182 mol) and ethyl 2-benzylacetoacetate (40 g, 0.182 mol) are mixed in 70% H2SO4 (350 mL) at 0° C. The reaction mixture is stirred at room temperature for 72 hours and poured into ice water. The solid is filtered and washed with water. The crude product is recrystallized from ethanol/chloroform to afford 6-chloro-7-hydroxy coumarin intermediate (37.52 g, 68.7%).
後処理
- filtrationThe solid is filtered
- washwashed with water
- customThe crude product is recrystallized from ethanol/chloroform
出典と根拠
- ORDレコード
- ord-b365926c56ad41a4b5dea9adf27d3d2b
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07994318B2
反応ノート
読み込み中…