Methanol → Methyl 2-fluoro-4-nitrobenzoate

HRID 1671660ノート

反応式

HRID 1671660 の反応式
S(=O)(=O)(O)O.[F:6][C:7]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10].[CH3:19]O>>[F:6][C:7]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([O:11][CH3:19])=[O:10]

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 3026792-Fluoro-4-nitrobenzoic acid

生成物 1

HCID 3013872Methyl 2-fluoro-4-nitrobenzoate

実験手順

Concentrated sulfuric acid (5 ml) was added to a methanol (1300 ml) solution of 2-fluoro-4-nitrobenzoic acid (140 g), and heated under reflux for 48 hours. The solvent was evaporated away under reduced pressure, water was added to it, and the formed solid was taken out through filtration. After dried under reduced pressure, the entitled compound was obtained as a yellow solid.

後処理

  1. temperatureheated
  2. temperatureunder reflux for 48 hours
  3. customThe solvent was evaporated away under reduced pressure, water
  4. additionwas added to it
  5. filtrationthe formed solid was taken out through filtration
  6. customAfter dried under reduced pressure
  7. customthe entitled compound was obtained as a yellow solid

出典と根拠

ORDレコード
ord-54c5adcb1a4140c1b230412f77f4fc8b
出典データセット
uspto-grants-2011_08
特許番号
US07994331B2

反応ノート

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