Water → HCID 23088640、化合物

HRID 16721ノート

反応式

HRID 16721 の反応式
[Br:1][C:2]1[N:7]=[C:6]([C:8]#[N:9])[C:5]([OH:10])=[CH:4][CH:3]=1.[CH2:11](Br)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+].O>CC(C)=O>[CH2:11]([O:10][C:5]1[C:6]([C:8]#[N:9])=[N:7][C:2]([Br:1])=[CH:3][CH:4]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

6

反応物 4

HCID 962WaterHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 230887086-Bromo-3-hydroxypyridine-2-carbonitrile

生成物 1

HCID 23088640HCID 23088640、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

6-Bromo-3-hydroxypyridine-2-carbonitrile (53.8 g) obtained in Reference Example 72(1) is dissolved in acetone (550 ml), and thereto are added benzyl bromide (35.6 ml) and potassium carbonate (43.1 g). The mixture is then heated under reflux for 4 hours. After allowing to cool, water (600 ml) is added to the reaction solution, and the mixture is extracted with ethyl acetate. The aqueous layer is extracted with ethyl acetate once, and combined with the previous organic layer. The solution is washed with saturated brine and dried over sodium sulfate. The solvent is removed by evaporation under reduced pressure and the residue is purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=5/1, followed by 3/1). The resulting residue is suspended in diethyl ether/n-hexane and the solid is collected by filtration to give the title compound (24.1 g).

後処理

  1. temperatureThe mixture is then heated
  2. temperatureunder reflux for 4 hours
  3. temperatureto cool
  4. extractionthe mixture is extracted with ethyl acetate
  5. extractionThe aqueous layer is extracted with ethyl acetate once
  6. washThe solution is washed with saturated brine
  7. dry with materialdried over sodium sulfate
  8. customThe solvent is removed by evaporation under reduced pressure
  9. customthe residue is purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate=5/1, followed by 3/1)
  10. filtrationthe solid is collected by filtration

出典と根拠

ORDレコード
ord-d7d873024a9949f3b97cb6962be4f2a7
出典データセット
uspto-grants-2010_06
特許番号
US07737161B2

反応ノート

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