HCID 67335596、化合物 → HCID 67335638、化合物
反応式
C([O:3][C:4](=O)[CH2:5][NH:6][CH2:7][C:8]1([NH:14][C:15]2[CH:16]=[C:17]3[C:21](=[CH:22][CH:23]=2)[NH:20][N:19]=[CH:18]3)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)C>Cl>[NH:20]1[C:21]2[C:17](=[CH:16][C:15]([N:14]3[C:8]4([CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]4)[CH2:7][NH:6][CH2:5][C:4]3=[O:3])=[CH:23][CH:22]=2)[CH:18]=[N:19]1参加物
3
実験手順
A mixture of {[1-(1H-indazol-5-ylamino)-cyclohexylmethyl]-amino}-acetic acid ethyl ester (0.808 g, 2.45 mmol) in 2N HCl (11 mL) was heated at reflux for 17 hours, then cooled to room temperature and quenched by the careful addition of K2CO3 until no more effervescence was observed. The resulting mixture was extracted with DCM and the combined extracts were dried (MgSO4), filtered and concentrated in vacuo to furnish 1-(1H-indazol-5-yl)-1,4-diaza-spiro[5.5]undecan-2-one (0.350 g, 1.23 mmol, 50%) as a solid that was used directly without further purification.
後処理
- temperaturewas heated
- temperatureat reflux for 17 hours