N-(2-Chlorophenyl)-6-methoxy-3-nitro-4-quinolinamine → HCID 60046938、化合物
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:19][CH3:20])[CH:17]=2)[N:12]=[CH:11][C:10]=1[N+:21]([O-])=O>CO.[Ni]>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:19][CH3:20])[CH:17]=2)[N:12]=[CH:11][C:10]=1[NH2:21]参加物
4
実験手順
The title compound is prepared in analogy to Example 19e, starting from 0.8 g (2.4 mmol) of (2-chloro-phenyl)-(6-methoxy-3-nitro-quinolin-4-yl)-amine (Example 44h) and 0.4 g Raney-Ni in 30 ml methanol. Time of hydrogenation: 1 h at rt. Crystallization of the product from ethyl acetate-hexane. mp: 120-123° C.; MS: 300 (M++1); HPLC: tret=8.41 min (Grad 1).
後処理
- custom1 h
- customat rt
- customCrystallization of the product from ethyl acetate-hexane
- customtret=8.41 min (Grad 1)
出典と根拠
- ORDレコード
- ord-631462b395b845c7821cec9167f6e423
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07998972B2
反応ノート
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