Hydrochloric Acid → HCID 67329989、化合物

反応式

C(OC(=O)[NH:7][CH2:8][CH2:9][S:10]([C:13]1[C:14]2[CH:15]=[CH:16][N:17]=[CH:18][C:19]=2[CH:20]=[C:21]([C:23]2[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=2)[CH:22]=1)(=[O:12])=[O:11])(C)(C)C.[ClH:32]>CO.O1CCOCC1>[ClH:32].[ClH:32].[CH3:30][O:29][C:26]1[CH:25]=[CH:24][C:23]([C:21]2[CH:22]=[C:13]([S:10]([CH2:9][CH2:8][NH2:7])(=[O:12])=[O:11])[C:14]3[CH:15]=[CH:16][N:17]=[CH:18][C:19]=3[CH:20]=2)=[CH:28][CH:27]=1

参加物

実験手順

Treat a slurry of {2-[7-(4-methoxy-phenyl)-isoquinoline-5-sulfonyl]-ethyl}-carbamic acid tert-butyl ester (11.00 g, 24.85 mmol) in anhydrous MeOH (150 mL) with 4N HCl in dioxane (350 mL). Stir the resulting reaction mixture at room temperature overnight, then concentrate in vacuo to ½ volume and treat with excess EtOAc, causing a yellow solid to precipitate. Recover the resulting solid by vacuum filtration under an N2 atmosphere; wash with EtOAc and dry under vacuum (under an N2 atmosphere) to afford the title compound (10.23 g, 99% yield) as a yellow solid: MS (ES): m/z 343.0 (M++H).