化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 3-Hydroxy-4-methyl-2-nitrobenzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 3-Acetamido-4-methyl-2-nitrobenzoic acid | HCID 243433 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Hydroxy-4-methyl-2-nitrobenzoic acid | HCID 81374 | 93.4% |
反応手順
A solution of 3-(acetylamino)-4-methyl-2-nitrobenzoic acid (237.5 g, 0.997 mol) and KOH (451.2 g, 8.04 mol) in water (2830 mL) was refluxed for 48 h. The dark red solution was cooled and acidified to pH 1 with concentrated HCl. The yellow solid was filtered and re-crystallized from water (1800 mL) to give the title compound (183 g, 93.4%) as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07998978B2 |
| 出典データセット | uspto-grants-2011_08 |
| ORD ID | ord-38c31f1419744cd699942a50b6d9a0af |
| 出典メモ | uspto-grants-2011_08 |