Hydrochloric Acid → HCID 67051864、化合物

HRID 1672923ノート

反応式

HRID 1672923 の反応式
[OH:1][C:2]1([CH:13]([OH:15])[CH3:14])[CH2:5][N:4](C(OC(C)(C)C)=O)[CH2:3]1.[ClH:16].O1CCOCC1>CO>[ClH:16].[OH:15][CH:13]([C:2]1([OH:1])[CH2:5][NH:4][CH2:3]1)[CH3:14]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 670516151-Azetidinecarboxylic acid, 3-hydroxy-3-(1-hydroxyethyl)-, 1,1-dimethylethyl ester

生成物 1

HCID 67051864HCID 67051864、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1,1-Dimethylethyl 3-hydroxy-3-(1-hydroxyethyl)azetidine-1-carboxylate (200 mg, 0.922 mmol) was dissolved in methanol (5 mL) and 4 N hydrochloric acid in dioxane (1 mL, 4 mmol) was added. The mixture was refluxed for 15 minutes and then was concentrated in vacuo to afford 3-(1-hydroxyethyl)azetidin-3-ol hydrochloride (0.922 mmol).

後処理

  1. temperatureThe mixture was refluxed for 15 minutes
  2. concentrationwas concentrated in vacuo

出典と根拠

ORDレコード
ord-00101cfe579f42a49baccb9a8b701c31
出典データセット
uspto-grants-2011_08
特許番号
US07999006B2

反応ノート

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