Methanol → HCID 57879314、化合物

HRID 1673453ノート

反応式

HRID 1673453 の反応式
CO.[C:3]([NH:11][C:12]1[CH:20]=[C:19]([CH:21]2[CH2:25][CH2:24][CH:23]=[CH:22]2)[CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15])(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>[C].[Pd].C(OCC)(=O)C>[C:3]([NH:11][C:12]1[CH:20]=[C:19]([CH:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)[CH:18]=[CH:17][C:13]=1[C:14]([OH:16])=[O:15])(=[O:10])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 2

HCID 887MethanolHCID 57879367HCID 57879367、化合物

生成物 1

HCID 57879314HCID 57879314、化合物

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8857Ethyl Acetate溶媒

実験手順

5.0 mg of 5% palladium-carbon was added to a mixed solution of 1.0 mL of methanol and 0.5 mL of ethyl acetate containing 25 mg of 2-(benzamido)-4-(2-cyclopenten-1-yl)benzoic acid and stirred at room temperature under hydrogen atmosphere for 7 hours and then at 40° C. for 8 hours and stirred at 45° C. for 15 hours. Insoluble were removed by filtration and the solvent was evaporated under reduced pressure. Methanol was added to the obtained residue and a solid substance was separated by filtration to obtain 16 mg of 2-(benzamido)-4-cyclopentyl benzoic acid as white solid.

後処理

  1. waitat 40° C. for 8 hours
  2. stirringstirred at 45° C. for 15 hours
  3. customInsoluble were removed by filtration
  4. customthe solvent was evaporated under reduced pressure
  5. additionMethanol was added to the obtained residue
  6. customa solid substance was separated by filtration

出典と根拠

ORDレコード
ord-78a3628595f74901b71bec602666574a
出典データセット
uspto-grants-2011_08
特許番号
US07999132B2

反応ノート

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